Is a processed dehydrated form of caffeine.
Category
Anhydrous means without water and caffeine anhydrous is a processed dehydrated form of caffeine. Caffeine anhydrous is becoming more popular as a supplement for weight loss and improved athletic performance. It is also present in food products such as caffeinated gum and energy bars.
Application
APPLICATION
Supplements
Caffeine anhydrous is used in weight loss supplements and supplements to improve athletic performance. It can also be used to treat fatigue and drowsiness.
Food and beverages
Caffeine anhydrous is used in caffeinated gum, energy bars, and other food and beverage products. It can also be used as a pharmaceutical ingredient.
Other applications
Caffeine anhydrous is used in pre-workout powder, diet pills, and as a performance enhancer for activities like running and cycling. It can also be used to treat migraine headaches, simple headaches, and headaches after epidural anesthesia.
Caffeine anhydrous is more concentrated than caffeine found in coffee, with one teaspoon of pure powdered anhydrous caffeine being equivalent to 2,700 milligrams of caffeine. It can have side effects, including headaches, insomnia, nausea, anxiety, and stomach upset.
Dose
Anhydrous means without water, and caffeine anhydrous, is a processed, dehydrated form of caffeine. Caffeine anhydrous is becoming more popular as a supplement for weight loss and improved athletic performance. It is also present in food products such as caffeinated gum and energy bars.
Technical specifications
PHYSICAL PROPERTIES
| Melting point | 235–238°C |
| Solubility | Moderately soluble in water at room temperature (2 g/100 mL), but quickly soluble in boiling water (66 g/100 mL). It's also soluble in chloroform, acetic acid, acetic anhydride, ethanol, and diethyl ether. |
| pH | A solution of caffeine (1 in 100) has a pH between 5.5 and 6.5 |
MSDS
| Product Name | Caffeine Anhydrous |
| Part Number | RXSOL-19-6604-002 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 27612100 :::AOH :0091 9821214367 |
| mail@rxmarine.com | |
| Website | www.rxmraine.com |
Substances
| Synonyms |
Caffeine free base
1,3,7-Trimethylxanthine
7-Methyltheophylline
|
| Formula | C8H10N4O2 |
| Molecular weight | 194,19 g/mol |
| CAS-No. | 58-08-2 |
| EC-No. | 200-362-1 |
| Index-No. | 613-086-00-5 |
| Component | Classification | Concentration |
| Caffeine | ||
|
CAS-No. 58-08-2
EC-No. 200-362-1
Index-No. 613-086-00-5
|
Acute Tox. 4; H302 | = 100 % |
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification of the substance or mixture
| Classification according to Regulation (EC) No 1272/2008 |
Acute toxicity, Oral (Category 4), H302
For the full text of the H-Statements mentioned in this Section, see Section 16.
|
Label elements
| Signal Word | Warning |
| Hazard Statements | H302 Harmful if swallowed. |
| Precautionary Statements | P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth. |
| Supplemental Hazard Statements | None |
| Reduced Labeling (= 125 ml) | |
| Signal Word | Warning |
| Hazard Statements | None |
| Precautionary Statements | None |
| Supplemental Hazard Statements | None |
| Other hazards |
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
|
| General Advice | Consult a physician. Show this material safety data sheet to the doctor in attendance. |
| If inhaled | If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. |
| In case of skin contact | Wash off with soap and plenty of water. Consult a physician. |
| In case of eye contact | Flush eyes with water as a precaution. |
| If swallowed | Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. |
| Most important symptoms and effects, both acute and delayed | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Suitable extinguishing media | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. |
| Special hazards arising from the substance or mixture |
Carbon oxides
Nitrogen oxides (NOx)
Combustible.
|
| Advice for firefighters | Wear self-contained breathing apparatus for firefighting if necessary. |
| Further information | No data available |
| Personal precautions, protective equipment and emergency procedures |
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
|
| Environmental precautions |
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
|
| Methods and material for containment and cleaning up | Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. |
| Reference to other sections | For disposal see section 13. |
| Precautions for safe handling | |
| Advice on safe handling | Avoid contact with skin and eyes. Avoid formation of dust and aerosols. |
| Advice on protection against fire and explosion | Provide appropriate exhaust ventilation at places where dust is formed. |
| Hygiene measures |
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
For precautions see section 2.2.
|
| Conditions for safe storage, including any incompatibilities | |
| Storage conditions | Keep container tightly closed in a dry and well-ventilated place. Store in cool place. |
| Storage class | Storage class (TRGS 510): 11: Combustible Solids |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
Control parameters
Ingredients with workplace control parameters
Personal protective equipment
| Eye/face protection | Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). |
| Skin protection |
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
|
| Body Protection | Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. |
| Respiratory protection | For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). |
| Control of environmental exposure |
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
|
| Physical state | Crystalline powder |
| Color | Colorless |
| Odor | Odorless |
| Melting point/freezing point | No data available |
| Initial boiling point and boiling range | No data available |
| Flammability (solid, gas) | No data available |
| Upper/lower flammability or explosive limits | No data available |
| Flash point | No data available |
| Autoignition temperature | No data available |
| Decomposition temperature | No data available |
| pH | No data available |
| Viscosity |
Viscosity, kinematic: No data available
Viscosity, dynamic: 0,83 mPa.s at 20 °C
|
| Water solubility | No data available |
| Partition coefficient: n-octanol/water | No data available |
| Vapor pressure | No data available |
| Density | No data available |
| Relative density | 1,23 at 18 °C |
| Relative vapor density | No data available |
| Particle characteristics | No data available |
| Explosive properties | No data available |
| Oxidizing properties | None |
| Other safety information | No data available |
| Reactivity | No data available |
| Chemical stability | Stable under recommended storage conditions. |
| Possibility of hazardous reactions | No data available |
| Conditions to avoid | No data available |
| Incompatible materials | Strong oxidizing agents |
| Hazardous decomposition products | In the event of fire: see section 5 |
| Acute toxicity |
LD50 Oral - Rat - male and female - 367,7 mg/kg
(OECD Test Guideline 401)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
LC50 Inhalation - Rat - male and female - 4 h - 4,94 mg/l - aerosol
(OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 2.000 mg/kg
(OECD Test Guideline 402)
|
| Skin corrosion/irritation |
Skin - Rabbit
Result: No skin irritation - 4 h
(OECD Test Guideline 404)
|
| Serious eye damage/eye irritation |
Eyes - Rabbit
Result: No eye irritation
(OECD Test Guideline 405)
|
| Respiratory or skin sensitization |
Local lymph node assay (LLNA) - Mouse
Result: negative
(OECD Test Guideline 429)
|
| Germ cell mutagenicity |
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Result: positive
Remarks: (ECHA)
Test Type: Ames test
Test system: Escherichia coli
Metabolic activation: without metabolic activation
Method: OECD Test Guideline 471
Result: positive
Test Type: In vitro mammalian cell gene mutation test
Test system: human lymphoblastoid cells
Metabolic activation: without metabolic activation
Method: OECD Test Guideline 476
Result: positive
Test Type: In vitro mammalian cell gene mutation test
Test system: human lymphoblastoid cells
Metabolic activation: without metabolic activation
Result: positive
Remarks: (ECHA)
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Result: positive
Remarks: (ECHA)
Test Type: unscheduled DNA synthesis assay
Test system: rat hepatocytes
Metabolic activation: without metabolic activation
Method: OECD Test Guideline 482
Result: positive
Test Type: Micronucleus test
Species: Mouse
Application Route: Intraperitoneal
Method: OECD Test Guideline 474
Result: negative
Test Type: Mutagenicity (mammal cell test): micronucleus.
Species: Mouse
Cell type: Red blood cells (erythrocytes)
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Test Type: sister chromatid exchange assay
Species: Rat
Cell type: mammary gland
Application Route: inhalation (vapor)
Result: negative
Remarks: (ECHA)
Species: Drosophila melanogaster
Cell type: sperm
Application Route: Inhalation
Method: OECD Test Guideline 477
Result: positive
Test Type: Transgenic rodent somatic cell gene mutation assay
Species: Mouse
Application Route: Intraperitoneal
Result: negative
Remarks: (ECHA)
|
| Carcinogenicity | No data available |
| Reproductive toxicity | No data available |
| Specific target organ toxicity - single exposure | No data available |
| Specific target organ toxicity - repeated exposure | No data available |
| Aspiration hazard | No data available |
| Additional Information |
Repeated dose toxicity - Mouse - male and female - Oral - 90 d - NOAEL (No observed
adverse effect level) - 167,4 - 179,4 mg/kg
Remarks: (ECHA)
RTECS: EV6475000
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
After absorption of toxic quantities:
Diarrhea
Vomiting
agitation
Headache
Systemic effects:
drop in blood pressure
tachycardia
Handle in accordance with good industrial hygiene and safety practice.
Liver - Irregularities - Based on Human Evidence
|
| Toxicity | |
| Toxicity to fish |
Static test LC50 - Leuciscus idus (Golden orfe) - ca. 87 mg/l - 96 h
(DIN 38412 part 15)
Static test NOEC - Leuciscus idus (Golden orfe) - 46 mg/l - 96 h
(DIN 38412 part 15)
|
|
Toxicity to daphnia
and other aquatic
invertebrates
|
Static test EC50 - Daphnia magna (Water flea) - 182 mg/l - 48 h
(DIN 38412)
|
| Toxicity to algae |
Static test ErC50 - Desmodesmus subspicatus (green algae) - > 100
mg/l - 72 h
(OECD Test Guideline 201)
Static test NOEC - Desmodesmus subspicatus (green algae) - 6,25
mg/l - 72 h
(OECD Test Guideline 201)
|
| Toxicity to bacteria |
EC50 - activated sludge - > 1.000 mg/l - 3 h
(OECD Test Guideline 209)
|
| Persistence and degradability | |
| Biodegradability |
aerobic - Exposure time 22 d
Result: 90 - 100 % - Readily biodegradable.
(OECD Test Guideline 301A)
|
| Bioaccumulative potential | No data available |
| Mobility in soil | No data available |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties | No data available |
| Other adverse effects |
Harmful to aquatic life.
Discharge into the environment must be avoided.
|
| Waste Treatment Methods | |
| Product | Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. |
| Contaminated packaging | Dispose of as unused product. |
| UN number | ADR/RID: IMDG: IATA: |
| UN proper shipping name |
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
|
| Transport hazard class(es) | ADR/RID: IMDG: IATA: |
| Packaging group | ADR/RID: IMDG: IATA: |
| Environmental hazards | ADR/RID: no IMDG Marine pollutant: no IATA: no |
| Special precautions for user | |
| Further information | Not classified as dangerous in the meaning of transport regulations. |
| Safety, health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. |
| Chemical Safety Assessment | A Chemical Safety Assessment has been carried out for this substance. |
| Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages. |